Michal Pěchouček has been involved in establishing several successful technology start-ups, including cybersecurity company Cognitive Security (acquired by Cisco in 2013), AgentFly Technologies, which focuses on autonomous air traffic control, and BlindSpot Solutions, an artificial intelligence company acquired by the Adastra Group in 2017. From 2019 to 2024, he served as Chief Technology Officer at Gen (formerly Avast), helping drive the company's AI and cybersecurity innovation.

During his tenure at Gen, Avast merged with NortonLifeLock in a transaction valued at more than $8 billion, creating one of the world's largest consumer cybersecurity companies. Prior to the merger, Avast was a constituent of the FTSE 100 with a market capitalization of approximately $7.2 billion. Under Pěchouček's technical leadership, the company strengthened its AI and machine-learning capabilities, particularly in threat detection, digital privacy, and consumer security.

As Director of the AI Center at the Czech Technical University in Prague (CTU), Pěchouček has authored more than 400 scientific publications in artificial intelligence and multi-agent systems. He previously led the Department of Computer Science, co-founded Open Informatics, and launched prg.ai to help establish Prague as a leading European AI hub. In 2026, he was elected Rector of the Czech Technical University in Prague, becoming the leader of one of Central Europe's largest and most prestigious technical universities.